Obese Patients Less Likely to Have Genetic Mutation Associated With Better Colorectal Cancer Outcomes

Researchers found obese patients were significantly less likely to have a tumor with deficient DNA mismatch repair status, a phenotype associated with improved outcomes in colorectal cancer, than normal-weight patients according to findings published in the Journal of Clinical Oncology.

Obese patients were more likely to have proficient DNA mismatch repair status, which is indicative of more aggressive disease. Analyzing information from 2,693 colon cancer patients with stage II or III disease, researchers found 16 percent of tumors had dMMR status. They also found 18 percent of women had the protective status while 14 percent of men did. Among obese patients, 13 percent of women had dMMR while 8 percent of men did.

Related Articles on Colorectal Cancer:
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Racial Colonoscopy Gap Persists Even When Physician Numbers Increase

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