The researchers identified 43 studies of serrated polyp risk associated with seven lifestyle factors: smoking, alcohol, body mass index, diet, physical activity, medication and hormone-replacement therapy.
Here’s what you need to know:
1. Factors that significantly increased risk included smoking, alcohol, BMI and high intake of fat or meat.
2. The risk associations for smoking and alcohol were stronger for sessile serrated adenomas/polyps than for hyperplastic polyps.
3. Factors that significantly decreased risk included use of nonsteroidal anti-inflammatory drugs, use of aspirin and high intake of folate, calcium or fiber.
4. There were no significant risk associations for either physical activity or hormone-replacement therapy.
The researchers concluded, “these findings enhance our understanding of mechanisms of SP development and indicate that risk of serrated pathway colorectal neoplasms could be reduced with lifestyle changes.”
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