Tissue-engineered small intestine successful — Is a new short bowel syndrome treatment next? 3 things to know

A study published in American Journal of PhysiologyGastrointestinal and Liver Physiology demonstrated both mouse and human tissue-engineered small intestine had the features of a small intestine.

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Here are three things to know from the study:

  • TESI could provide a therapeutic alternative to the current standard treatment of SBS, solving challenges such as donor shortages in regard to transplants of the intestine as well as immunosupression.
  • Researchers previously demonstrated TESI replicates key components of native intestine.
  • The new study shows TESI holds a “well-differentiated epithelium with intact ion transporters/channels, functional brush-border enzymes and similar ultrastructural components to native tissue, including progenitor cells, whether derived from mouse or human cells.”

You can view the study abstract here.

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