Extended PPI use not associated with cognitive decline — 4 insights

Prolonged proton pump inhibitor use did not cause cognitive decline in middle-aged and older individuals, according to two studies from Denmark, Medpage Today reports.

Here's what you should know:

1. Study researchers examined 2,346 middle-aged individuals (median age of 57 years) over 10 years and 2,475 older individuals (median age of 75 years) over two years. In both instances researchers failed to find a statistically significant effect of long-term PPI exposure on cognitive function.

2. Researchers said they saw no instances of cognitive decline when comparing baseline scores to follow-up scores.

3. Researchers concluded the results were in line with another study that showed there was no link between PPI use and mild cognitive impairment.

4. Researchers did note their 2-year follow-up time could've been too short to recognize any long-term cognitive decline.

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