Increased intestinal epithelial cell apoptosis is a hallmark of inflammatory bowel disease. Mutations in p53 appear early in the progression to colitis-induced cancer. The study explored the role of p53 and its target PUMA to mediate inflammation-induced IEC apoptosis.
The study found that inflammation-induced IEC apoptosis utilizes p53 mechanisms that are dependent and independent of PUMA and intrinsic apoptosis pathway activation, meaning that both p53 and PUMA regulate IEC apoptosis in colitis.
Read the abstract in Gastroenterology on colitis.
Related Articles on Colitis:
Study: Probiotic-Derived Protein can Protect Intestinal Cells From Inflammation
3 Young Gastroenterologists Win AGA Research Scholar Awards
FDA Approves Test to Quickly Detect Intestinal Infection
At the Becker's 23rd Annual Spine, Orthopedic and Pain Management-Driven ASC + The Future of Spine Conference, taking place June 11-13 in Chicago, spine surgeons, orthopedic leaders and ASC executives will come together to explore minimally invasive techniques, ASC growth strategies and innovations shaping the future of outpatient spine care. Apply for complimentary registration now.
