Ronnie Fass, MD, of Cleveland-based Case Western Reserve University, and colleagues conducted a systematic review and meta-analysis of 28 studies representing 2,468 patients. They included four randomized controlled trials, 23 cohort studies and one registry using generalized inverse weighting for all outcomes.
Here’s what you should know.
1. The unweighted mean follow-up time was 25.4 months (3 months to 120 months).
2. Pooled results showed that Stretta reduced quality of life scores by -14.6 (improved by 60 percent).
3. Stretta reduced heartburn standardized score by -1.53 (improved by 58 percent).
4. After a Stretta procedure, only 49 percent of patients using proton pump inhibitors required the proton pump inhibitors at follow-up.
5. Stretta reduced incidences of erosive esophagitis by 36 percent (fixed effects model), and reduced esophageal acid exposure by a mean -3.01 and normalized acid in 30 percent of subjects tested.
6. Stretta increased lower esophageal sphincter basal pressure by a mean of 1.73 mmHg.
Researchers concluded, “The Stretta procedure significantly improves subjective and objective clinical endpoints, except LES basal pressure, and therefore should be considered as a viable alternative in managing GERD.”
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