Roger Williams Medical Center to study liver cancer: 4 things to know

Providence, R.I.-based Roger Williams Medical Center is starting a phase Ib clinical trial onCAR-T hepatic artery infusions delivered using the Surefire Infusion System for CEA-expressing liver metastases.

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Here are four things to know:

1. Participants will undergo white blood cell collection via a leukapheresis procedure. These cells will be modified to attack cancer; after modification, these cells are called “CAR-T cells.”

2. After two to three weeks, the cells are returned to the patient, at which point they will receive three CAR-T infusions delivered directly into the liver once a week for a duration of 10 weeks.

3. Low dose interleukin-2, a protein produced by T-cells, will be delivered by a portable pump during the T-cell infusion period.

4. At the end of the 10-week period, a final imaging test is performed.

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