• The first tumor type examined was type 1 (microsatellite instability [MSI]–high, CpG island methylator phenotype [CIMP] –positive, positive for BRAF mutation, negative for KRAS mutation).
• The second tumor type examined was type 2 (microsatellite stable [MSS] or MSI-low, CIMP-positive, positive for BRAF mutation, negative for KRAS mutation).
• The third tumor type examined was type 3 (MSS or MSI low, non-CIMP, negative for BRAF mutation, positive for KRAS mutation).
• The fourth tumor type examined was type 4 (MSS or MSI-low, non-CIMP, negative for mutations in BRAF and KRAS).
• The fifth tumor type examined was (MSI-high, non-CIMP, negative for mutations in BRAF and KRAS).
• The researchers found that type four tumors were the most common.
• Patients with type 2 tumors had the highest disease-specific mortality rate. Patients with type 3 tumors also had a high disease-specific mortality rate.
• Patients with type 5 tumors had the lowest disease-specific mortality rate.
• The researchers concluded that molecular heterogeneity of colorectal cancer plays an important role in understanding and combating the disease.
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