ACG developed the guideline due to advances in diagnostic testing and therapeutic options. The guideline was developed using the Grading of Recommendations, Assessment, Development and Evaluation methodology.
Researchers answered 25 clinically important questions on IBS. Nine of the questions focused on diagnostic questions and 16 questions focused on therapeutic options.
ACG endorsed several practices. Physicians should:
- Use a positive diagnostic strategy to initiate an appropriate therapy
- Use serologic testing to rule out celiac disease
- Check calprotectin in patients with suspected IBS and diarrhea symptoms to rule out IBS
- Use a limited diet of low fermentable oligosaccharides, disaccharides, monosaccharides and polyols to improve IBS
- Use chloride channel activators and guanylate cyclase activators to treat IBS with constipation
- Use rifaximin to treat IBS with diarrhea
- Use gut-directed psychotherapy to treat IBS
Read the entire guideline here.
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