Study: Isoflurane Exposure Led to Apoptotic Cell Death in Mice

Newborn mice experienced apoptotic cell death after exposure to the anesthetic agent isoflurane, according to a study published in Anesthesia-Analgesia.

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Researchers from the University of Cincinnati’s department of anesthesia tested seven-day-old mice who received six-hour exposure to either 1.5 percent isoflurane or room air. Exposure to the anesthesia led to widespread increase in apoptotic cell death, eliminating approximately 2 percent of cortical neurons.

The clinical relevance of the findings has yet to be determined.

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