Blocking Receptor Might Help Control Post-Surgery Pain and Inflammation

Using drugs to block the IL-1 receptor might help control post-surgery pain, according to a paper published in the Dec. 2010 issue of Anesthesia & Analgesia.

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The study showed that the common practice of injecting local anesthetics into surgical incisions may lead to increased inflammation and interfere with wound healing. According to the report, the signaling molecule interleukin-1 helps regulate inflammation in response to wounds.

A bupivacaine injection into the incision caused a disruption of anti-inflammatory mechanisms in the incision, according to the authors.

Read the Anesthesia & Analgesia report on the IL-1 receptor.

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