Felicia Goldstein, PhD, of Atlanta-based Emory University, and colleagues conducted an observational, longitudinal study of 10,486 patients aged 50 years and older. Of the patient base, 884 took PPIs at every visit, 1,925 took PPIs intermittently and 7,677 never took PPIs.
Researchers used multivariable Cox regression analyses measure the PPI use and cognition guidelines.
Here’s what they found:
1. Continuous PPI use was linked to a lower risk in cognitive function decline or conversion to mild cognitive impairment or Alzheimer’s disease.
2. Researchers said intermittent use presented a lower risk in both of the aforementioned criteria.
3. Researchers said a potential study limitation was the self-reported PPI metric use and the lack of dispensing data. They recommend a prospective study to confirm the results.
Researchers concluded, “Proton pump inhibitors were not associated with greater risk of dementia or of AD, in contrast to recent reports.”
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