Benefits of Muscle Relaxants, Neuromodulators for Rheumatoid Arthritis Pain Don't Outweigh Side Effects

Researchers found the benefits of muscle relaxants and neuromodulators for treating rheumatoid arthritis pain don't outweigh the side effects, according to a news release.

Researchers looked at muscle relaxants — including benzodiazepine agents diazepam and triazolam and non- benzodiazepine agent zopiclone — and found they did not reduce pain when taken for up to two weeks, but use was associated with drowsiness and dizziness. They also looked at neuromodulators — including oral nefopam, topical capsaicin and oromucosal cannabis — and found weak evidence to support pain reduction. Use was associated with nausea, sweating, dizziness, dry mouth, light headedness, local burning and irritation.

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