Activation of the WNT signaling pathway, a network of proteins linked to cancer processes, and cadherin-associated protein beta-1 (CTNNB1) play a critical role in colorectal carcinogenesis, stories have shown.
Growing evidence indicates a role of WNT-CTNNB1 signaling in obesity and metabolic diseases. Considering the dual roles of CTNNB1 in carcinogenesis and energy metabolism, the authors hypothesized that activation of WNT-CTNNB1 signaling might provide proliferative ability to cancer cells.
In the study, obese patients with positive status for nuclear CTNNB1 were associated with significantly better colorectal cancer-specific survival and overall survival. Among non-obese patients, in comparison, positive status for nuclear CTNNB1 was not significantly associated with cancer-specific survival or overall survival.
Read the JAMA Abstract on colorectal cancer.
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