Joseph W. Leung, MD, and his colleagues conducted a randomized, controlled trial in which 10 mL of 0.8 percent indigo carmine was added to each 1 liter of water. Two groups of 84 patients each were given water-infusion colonoscopies with and without indigo carmine. The adenoma detection rate in the indigo carmine group was 62 percent, while the rate in the water-only group was 44 percent.
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