Instead of taking random tissue samples, physicians use an endoscope from which short bursts of light search areas suspected of having pre-cancerous cells. When the light hits the tissue, it scatters, and physicians can look for abnormalities to detect dysplasia.
The team has developed a technology called angle-resolved low coherence interferometry which shines light into a cell. Sensors capture and analyze the reflected light. The technology separates the patterns of the nucleus from other parts of the cell and can provide representations of shape changes.
In a clinical study, the system was 85 percent accurate when compared to pathological findings. The system was 86 percent accurate for pinpointing Barrett’s esophagus.
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