2 popular FIT tests detect advance neoplasia equally — 4 insights

A study, published in Gastroenterology, compared the effectiveness of FOB-Gold and OC-Sensor in detecting advanced neoplasia.

Researchers performed a large, prospective cohort study through the Dutch national CRC screening program. Researchers selected 22,064 screening-naïve individuals and had them do both tests with the same bowel movement. FITs were completed for 21,708 participants. Those participants with positive results underwent a colonoscopy.

Here's what they found:

1. A total of 2,112 participants had a positive result from one or both of the FITs, and 1,778 underwent a colonoscopy to confirm the diagnosis.

2. FOB-Gold detected advanced neoplasia in 610 participants while OC-Sensor detected advanced neoplasia in 606 participants.

3. Of the 21,078 patients who took both tests, 1,582 had a positive result from FOB-Gold, and 1,627 had a positive result from OC-Sensor.

4. The relative true positive rate was 0.97 for FOB-Gold and 0.95 for OC-Sensor.

Researchers concluded, "In a large, prospective study of individuals invited for CRC screening in The Netherlands, we found no significant difference in the ability of the FOB-Gold FIT versus the OC-Sensor FIT to detect advanced neoplasia. These results are relevant for selecting FITs for CRC screening programs worldwide."

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