One hundred and sixty-eight children undergoing abdominal or bone and joint surgeries were tested for various polymorphisms of six genes known to have a possible impact on pain.
The risk of elevated pain was 3.5 times higher for children with a gene OPRM, a receptor for opioid binding. However, though the gene variants affected pain score, they did not affect the dosage of opioid medications used from the patient-controlled analgesia.
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