According to the study, researchers have previously reported that propofol inhibits gap junction function briefly, and a functional GJ enhances the efficacy of radiotherapy in some cancer cells. The study examined the role of propofol in clinically relevant concentrations in the modulation of radiograph-induced cytotoxicity in HeLa cells transfected with connexin 32 plasmid. The role was explored by manipulating connexin expression, GJ presence and function.
The study found that propofol significantly reduced radiograph-induced cytotoxicity in the presence of functional GJ.
Read the study on propofol in Anesthesia & Analgesia.
Read more on anesthesia:
–ASA Updates Guidelines on Chronic Pain Management
–Study: Obese Patients Twice as Likely to Develop Airway Problems During General Anesthesia
