Cambridge, Mass.-based Yin Cao, Sc.D., and colleagues examined the association of antibiotic use and the colorectal adenoma risk. They evaluated the association between the factors in 20-to-39 year old women and in 40-to-59 year old women. Researchers used patients enrolled in the Nurses’ Health Study and patients that underwent at least one colonoscopy.
Here’s what they found.
1. Of 1,195 adenoma cases, researchers associated increased antibiotic use when a patient is between 20-years-old and 39-years-old with increased colorectal adenoma development risk.
2. Women who used antibiotics for more than two months between 20 and 39-years-old had a multivariable incidence of 1.36.
3. Women who used antibiotics for more than two months between 40 and 59-years-old had a multivariable incidence of 1.69.
4. The associations were similar for low- and high-risk adenomas, but were stronger for proximal than distal adenomas.
5. Researchers said recent antibiotic use within the past four years had no association with adenoma risk.
Researchers concluded, “Long-term antibiotic use in early-to-middle adulthood was associated with increased risk of colorectal adenoma.”
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