Gabapentin Does Not Decrease Pain After Total Knee Arthroplasty
Gabapentin does not decrease pain before and after patients undergo primary total knee arthroplasty, according to a study reported in Anesthesiology News.
The study showed no significant difference after surgery in the use of morphine, pain scores or length of stay in the hospital between patients who were randomly assigned to gabapentin or a placebo.
The study examined 101 patients who were randomized to gabapentin or a placebo before and after TKA. Perioperatively, the patients received the study medication orally, as well as a standard spinal anesthesia with hyperbaric bupivacaine combined with fentanyl. Postoperatively, the patients were given IV morphine for three days and 200 mg of gabapentin or placebo orally every eight hours.
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