Investigators examined use of tapentadol, which has µ-opioid receptor agonist and norepinephrine reuptake inhibitor activity, for moderate-to-severe chronic osteoarthritis knee pain or low back pain.
There were no significant differences between tapentadol ER and a placebo or oxycodone CR in changes from baseline to endpoint in blood pressure or heart rate.
Read the Clinical Advisor on pain.
Related Articles on Analgesics for Pain Management:
Dr. Bruce Nicholson Presents Four Strategies to Tackle Post-Op Pain
Study: Certain Analgesia Decreases Phantom Limb Pain
Drug Response Profile Dependent on Pain Mechanism and Opioid Type
