Findings on Chronic Pain Gene May Lead to New Drugs

Scientists have discovered how the gene HCN2 causes chronic neuropathic pain, clearing the way for possible development of a drug to reduce pain by blocking a protein the gene produces, according to a University of Cambridge news release.

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Scientists at the University of Cambridge in England studying the HCN2 gene, which is expressed in pain-sensitive nerve endings, have published their findings in the journal Science.

 

Engineering the removal of the HCN2 gene from pain-sensitive nerves in mice, researchers carried out studies using electrical stimuli on these nerves in cell cultures to determine how their properties were affected.

 

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