The study used data from the National Birth Defects Prevention Study, an ongoing population-based case-control study. The researchers estimated adjusted odds ratios and 95 percent confidence intervals for birth defects categories with at least 200 case infants or at least 4 exposed case infants. Therapeutic opioid use was reported by 2.6 percent of 17,449 case mothers and 2 percent of 6,701 control mothers. Use of opioids before or during early pregnancy was tied to defects such as conoventricular spetal defects, atrioventricular septal defects, hypoplastic left heart syndrome, spina bifida and gastroschisis.
Read the abstract on the study of birth defects in the American Journal of Obstetrics and Gynecology.
Read more on opioids:
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