Activation of the WNT signaling pathway, a network of proteins linked to cancer processes, and cadherin-associated protein beta-1 (CTNNB1) play a critical role in colorectal carcinogenesis, stories have shown.
Growing evidence indicates a role of WNT-CTNNB1 signaling in obesity and metabolic diseases. Considering the dual roles of CTNNB1 in carcinogenesis and energy metabolism, the authors hypothesized that activation of WNT-CTNNB1 signaling might provide proliferative ability to cancer cells.
In the study, obese patients with positive status for nuclear CTNNB1 were associated with significantly better colorectal cancer-specific survival and overall survival. Among non-obese patients, in comparison, positive status for nuclear CTNNB1 was not significantly associated with cancer-specific survival or overall survival.
Read the JAMA Abstract on colorectal cancer.
Related Articles on Colorectal Cancer:
Childhood Cancer Therapy Patients at Increased Risk of GI Complications
Meta-Analysis Shows Higher Vegetable, Fruit Intake Decreases Risk of Colorectal Cancer
Study Shows No Link Between Folates, Colorectal Cancer
At the Becker’s 32nd Annual Meeting: The Business and Operations of ASCs, taking place October 29-31 in Chicago, ASC leaders, surgeons and healthcare executives will explore strategies to drive growth, enhance operational performance, navigate reimbursement challenges and prepare for the future of ambulatory surgery. Apply for complimentary registration now.
