Pain Pill Celebrex May Decrease Risk of CRC, But Not Without Increasing Risk of Heart Problems

Patients who take the pain pill Celebrex may be less likely to develop polyps and colorectal cancer but may also be at increased risk of developing cardiovascular problems, according to a study published in the American Journal of Gastroenterology.

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This study adds to the growing body of medical literature that suggests Celebrex and other similar drugs, also known as COX-2 inhibitors, may yield negative outcomes for patients seeking to curb the risk of colorectal cancer.

For this study, researchers recruited 1,561 individuals with a history of colorectal cancer. More than half of the subjects received Celebrex for three years before researchers were forced to stop the study due to concerns about cardiovascular complications. The researchers obtained consent from half of the original study group, which continued to receive Celebrex.

Results from the study showed over the five-year study period, Celebrex subjects were less likely to develop polyps that could lead to colorectal cancer compared to placebo subjects. However, Celebrex users faced a 66 percent higher risk of developing serious cardiac conditions.

Read the study about the advantages and disadvantages of Celebrex.

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