Two Samples in FIT Testing Improves Diagnostic Yield Without Affecting Attendance

Researchers found collecting two samples during fecal immunochemical tests can improve diagnostic yield without affecting patients’ attendance to scheduled tests, according to a study published in Clinical Gastroenterology and Hepatology.

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More than 5,000 test subjects aged 50-74 years underwent a one-sample FIT screening, while another 3,197 test subjects underwent a two-sample FIT screening. The two-sample group collected fecal samples on two consecutive days. If any subjects tested positive with at least one sample, they were referred for colonoscopy.

Results showed subject attendance was 61.5 percent and 61.3 percent in the one-sample and two-sample group, respectively. Further, 8.1 percent of subjects in the one-sample group tested positive. By comparison, 12.8 percent of subjects in the two-sample group received one positive test outcomes and 5 percent had two positive test outcomes. Similarly, advanced neoplasia detection rates were 3.1 percent for the one-sample group, compared to 4.1 percent of patients with one positive outcome and 3.7 percent of patients with two positive outcomes in the two-sample group.

Read the study about two samples in fecal immunochemical testing.

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