6 Risk Factors for Clostridium Difficile Infection Relapse

Researchers have identified six risk factors for Clostridium difficile infection relapse, according to a study in Infection Control and Hospital Epidemiology.

The researchers used a clinical data warehouse at a four-hospital healthcare organization to gather information on inpatients who contracted C. difficile and were available for 56 days of follow-up. Data was collected from January 2006 through October 2010 and revealed a 23.9 percent rate of infection relapse, defined as a positive test of C. difficile between 15 and 56 days after the initial test.


The researchers identified the following factors associated with risk of relapse:

•    Age
•    Fluoroquinolone exposure in the 90 days before diagnosis
•    Intensive care unit stay in the 30 days before diagnosis
•    Cephalosporin exposure after diagnosis
•    Proton pump inhibitor exposure after diagnosis
•    Metronidazole exposure after diagnosis

The authors also determined that a prediction model in an electronic health record would flag 14.6 percent of CDI episodes at risk for relapse.

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