Study: Harmful Levels of Methemoglobin Can Be Detected With New Technique

Potentially harmful levels of methemoglobin, which can build in patients receiving certain anesthetics, can be detected using a new, non-invasive monitoring technique called pulse CO-oximetry, according to a study in the Nov. 2010 issue of Anesthesia & Analgesia.

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The new technique has an advantage over conventional pulse oximetry, which cannot detect methemoglobin. According to Steven L. Shafer, MD, editor-in-chief of Anesthesia & Analgesia, prior to the development of CO-oximetry, methemoglobinemia was nearly invisible in the OR.

Pulse CO-oximetry uses several different light wavelengths to assess methemoglobin levels, along with several other measures. In the study, 12 health volunteers were given sodium nitrite to raise their methemoglobin levels, then levels were monitored using the pulse CO-oximeter. The results were compared with measurements made directly in blood samples, and the pulse CO-oximeter provided “acceptable accurate” at monitoring levels.

Read the Newswise report on the study on pulse CO-oximetry.

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