Increased intestinal epithelial cell apoptosis is a hallmark of inflammatory bowel disease. Mutations in p53 appear early in the progression to colitis-induced cancer. The study explored the role of p53 and its target PUMA to mediate inflammation-induced IEC apoptosis.
The study found that inflammation-induced IEC apoptosis utilizes p53 mechanisms that are dependent and independent of PUMA and intrinsic apoptosis pathway activation, meaning that both p53 and PUMA regulate IEC apoptosis in colitis.
Read the abstract in Gastroenterology on colitis.
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