Findings showed that in patients ventilated for five hours during elective surgery, NLRP3 levels in alveolar macrophages were increased. The study also found NLRP3 inflammasome-deficient mice displayed less ventilator-induced lung injury from mechanical ventilation compared with normal mice.
“Another major finding from our study was that treatment with interleukin-1 receptor antagonist or glibenclamide also reduced ventilator-induced lung injury,” said lead study author Maria Kuipers, MD. “We believe these results can help improve future treatment possibilities in which the NLRP3 inflammasome may serve as a potential therapeutic target.”
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