Completing at-home CRC screening cuts cancer deaths 43%

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Patients who actually completed an at-home colorectal cancer screening kit had a 43% lower risk of dying from the disease, according to a study published Aug. 21 in JAMA Network Open.

Researchers from Karolinska Institutet and Umeå University re-evaluated 14 years of follow-up data from Sweden’s Stockholm-Gotland screening program, covering 376,511 participants and 1,668 colorectal cancer deaths. The program uses at-home fecal occult blood test kits, with positive results triggering a colonoscopy referral.

Three findings, by analysis method:

  1. Patients who completed the test: 43% lower mortality risk.
  2. Patients merely invited to screen, regardless of participation: 26% lower risk.
  3. The program’s original headline estimate: just 14% reduction.

The gap between the original 14% figure and the new 43% figure comes from correcting for two things prior evaluations missed: contamination (about two-thirds of the “unscreened” control group eventually got screened anyway) and nonadherence among those invited.

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