A study published in American Journal of Physiology - Gastrointestinal and Liver Physiology demonstrated both mouse and human tissue-engineered small intestine had the features of a small intestine.
Here are three things to know from the study:
- TESI could provide a therapeutic alternative to the current standard treatment of SBS, solving challenges such as donor shortages in regard to transplants of the intestine as well as immunosupression.
- Researchers previously demonstrated TESI replicates key components of native intestine.
- The new study shows TESI holds a "well-differentiated epithelium with intact ion transporters/channels, functional brush-border enzymes and similar ultrastructural components to native tissue, including progenitor cells, whether derived from mouse or human cells."
You can view the study abstract here.