Study suggests effectiveness of donor fecal microbiota transplantation: 5 insights

A recent study published in the Annals of Internal Medicine found that fecal microbiota transplantation from a donor is more effective than self transplantation when treating Clostridium difficile infection, according to Medscape.

Here's what you need to know:

1. The researchers randomly assigned 46 patients to receive either donor or self stool preparations by colonoscopy. They assessed these patients for six months, noting cessation of diarrhea, among other outcomes.

2. They found that 90.9 percent of patients who received donor fecal microbiota transplantation were clinically cured, compared with only 62.5 percent of patients who received self fecal microbiota transplantation.

3. Microbiome analysis of patients' gut microbial diversity showed a restoration of normal microbiota with donor stool — but no improvement with the self stool preparation.

4. However, the researchers also found a wide variation in the success rates of patients treated with self transplantation in different study locations, suggesting the need for additional research.

5. The researchers conclude that additional research might help to determine what types of patients benefit from donor stool.

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