Stool-Based DNA Test Detects 92% of Colorectal Cancers

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Exact Sciences announced the results of its DeeP-C clinical study comparing the efficacy of Cologuard, a multi-target stool DNA-based screening test, to the fecal immunochemical test.

The study found:

•    Cologuard detected 92 percent of colorectal cancer, compared to 74 percent in FIT
•    Cologuard detected 93 percent of colorectal cancers in Stages I-III, while FIT detected 73 percent
•    Cologuard demonstrated a 42 percent sensitivity level in patients with advanced precancerous lesions, while FIT demonstrated 24 percent sensitivity
•    Cologuard detected 69 percent of patients with high-grade dysplasia polyps, while FIT detected 46 percent
•    Cologuard had a specificity of 87 percent, while FIT had specificity of 95 percent

The results of the study were published in the New England Journal of Medicine.

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