Postop NSAIDs increases anastomotic complication risk among colorectal resection patients, study finds

Use of postoperative nonsteroidal anti-inflammatory drugs resulted in a significantly increased risk for anastomotic complications among some patients undergoing nonelective colorectal resection, according to a study published in JAMA Surgery.

Researchers conducted a retrospective cohort study of 13,082 patients undergoing bariatric or colorectal surgery. They also used data from the Surgical Care and Outcomes Assessment Program linked to the Washington State Comprehensive Abstract Reporting System. NSAID administration began within 24 hours after surgery.

Of the 13,082 patients, 3,158 (24.1 percent) received NSAIDs. The overall 90-day rate of anastomotic leaks was 4.3 percent for all patients in the NSAID group and 4.2 percent in the non-NSAID group.

After risk adjustment, NSAIDs were associated with a 24 percent increased risk for anastomotic leak. This association was isolated to nonelective colorectal surgery.

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