Patients who continue to use proton pump inhibitors after an initial episode of Clostridium difficile infection remained at an elevated risk of CDI recurrence, according to a study published in JAMA Internal Medicine.
Researchers conducted a retrospective cohort study of incident healthcare–associated CDI cases to determine the association between continuous PPI use and CDI recurrence within 90 days.
The cohort consisted of 754 patients who developed CDI. The study found the cause-specific hazard ratios for recurrence were 1.5 for patients older than 75 years, 1.5 for patients with continuous PPI use, 1.003 per day for length of stay and 1.3 for antibiotic re-exposure. The use of PPIs was common, with only 47.1 percent of patients having an evidence-based indication.
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