Early general anesthesia exposure may not impact neurodevelopment: 3 study insights

A study in Anesthesiology found that early general anesthesia exposure is not associated with neurological impairment — however, there were neurodevelopmental deficits for some children.

The researchers identified 18,056 children, 3,850 of whom had a single general anesthesia exposure and 620 of whom had two or more general anesthesia exposures; these children were matched with 13,586 children with no history of exposure to general anesthesia. All of the children with general anesthesia had been exposed before the age of 4 years old.

Here's what you need to know:

1. In children less than 2 years of age, there was no independent association between single or multiple general anesthesia exposure and neurodevelopmental capabilities.

2. However, a single exposure to general anesthesia between the ages of 2 and 4 years old was associated with neurodevelopmental deficits; these deficits related to communication/general knowledge and language/cognition capabilities.

3. Multiple general anesthesia exposures were not associated with greater risk than a single general anesthesia exposure.

The researchers concluded that "these findings refute the assumption that the earlier the GA exposure in children, the greater the likelihood of long-term neurocognitive risk."

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